尼古丁成瘾的神经环路机制研究组
课题组长
陈祖昕，博士，副研究员，中科院“百人计划”候选人。2007-2013年于华中科技大学攻读博士学位，博士导师为徐涛院士。2008-2010年于马克斯普朗克生物物理化学研究所（Gottingen）进行博士生联合培养。 2010-2013年于马克斯·普朗克佛罗里达神经科学研究所（Jupiter）进行博士生联合培养，导师为Samuel Young 副教授。2014-2018年期间于西奈山医学院从事博士后研究，导师为神经科学系系主任，药物研发中心主任 Paul Kennny 教授。2019年初加入中国科学院深圳先进技术研究院脑认知与脑疾病研究所担任副研究员。相关研究工作发表在Nature Neuroscience，Biological Psychiatry等顶级期刊杂志。
研究方向
1）尼古丁成瘾和戒断的机制解析
2）吸烟导致糖尿病的机制解析
3）戒烟药物和降糖药物研发
发表论文
1.Liu XA, Aguirre CA, Yang Q, Ren J, Wang L, Ju F, Guo H, Wang J, Liu L, Li Z, He J, Xu Z, Shi C, Cintron-Colon R, Michel T, Wood M, Margetts AV, Pollock TA, Vilca SJ, Tuesta LM, Di Angelantonio S, Basilico B, De Stefano ME, Xia J, Wei P, Li S, Yang X, Wang L, Delorme-Walker VD, Marcondes MCG, Parsons L, Conti B, Chen Z. Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents. Mol Psychiatry. 2025 Aug 7.
2.Jia S, Jing X, Wang R, Su M, Wang P, Feng Y, Ren X, Tu L, Wei P, Lu Z, Jia Y, Hong F, Mo Z, Zou J, Huang K, Yan C, Zou Q, Wang L, Zhong G, Zeng Z, Yu Q, Su W, Yang X, Pan F, Wang J, Wang L, Kang L, Kenny PJ, Chen Z, Liu XA. Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice. Advanced science. 2025 Jul 28:e15311.
3.Xu X, Zheng S, Ren J, Li Z, Li J, Xu Z, Yuan F, Yang Q, Margetts AV, Pollock TA, Vilca SJ, Yang C, Chen G, Shen P, Li S, Xia J, Chen C, Zhou T, Zhu Y, Tuesta LM, Wang L, Kenny PJ, Liu XA, Chen Z. Hypothalamic CRF neurons facilitate brain reward function. Curr Biol. 2024 Jan 22;34(2):389-402.e5.
4.Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O’Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma’ayan A, O’Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ. Habenular TCF7L2 links nicotine addiction to diabetes. Nature. 2019 Oct;574(7778):372-377
5. Jia X, Liu XA, Shi Y, Yao S, Zhong X, Tian Y, Tian Q, Chen Z, Wang L. Profiling of key brain nuclei involved in CNS control of stress and glucose homeostasis. Biochem Biophys Res Commun. 2020 Jan 8;521(2):441-448.
6. Chen Z, Kenny PJ. Endocannabinoid Signaling in the Habenula Regulates Adaptive Responses to Stress. Biol Psychiatry. 2018 Oct 15;84(8):553-554.
7. Passlick S, Thapaliya ER, Chen Z, Richers MT, Ellis-Davies GCR. Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J Physiol. 2018 Nov;596(22):5307-5318.
8. Tuesta LM, Chen Z, Duncan A, Fowler CD, Ishikawa M, Lee BR, Liu XA, Lu Q, Cameron M, Hayes MR, Kamenecka TM, Pletcher M, Kenny PJ. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci. 2017 May;20(5):708-716.
