药物成瘾的非人灵长类模型研究组
课题组长
孟志强, 博士, 正高级工程师， 2010年于中国科学院昆明动物研究所取得博士学位， 先后在哈佛大学医学院新英格兰灵长类研究中心 (2010-2013)，密西西比大学医学中心 (2013-2017) 和布兰迪斯大学 (2017-2019) 从事博士后工作，具有丰富的药物成瘾研究经验，在Current Biology, JPET，Drug Alcohol Dependence等国际期刊发表多篇关于药物成瘾的专业论文。
研究方向
1. 苯二氮平类药物成瘾性的机制
以非人灵长类动物为动物模型，采用经典的静脉自给药和条件位置偏好行为模型， 结合药理学、电生理和神经调控手段，研究苯二氮平产生成瘾性的分子和神经环路机制。
2. 药物成瘾干预策略
通过上述成瘾性机制的研究，一方面研发新的不作用于成瘾性相关的分子和环路靶点的药物，另一方面通过神经调控手段，如光遗传、深部脑刺激、经颅神经刺激等手段来研究干预药物依赖的可行性技术手段。
发表论文
1. Zhang G, Li L, Kong Y, Xu D, Bao Y, Zhang Z, Liao Z, Jiao J, Fan D, Long X, Dai J, Xie C, Meng Z, Zhang Z. Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder. Genes Dis. 2023; 11(2):1009-1021.
2. Meng Z, Berro LF, Sawyer EK, Ruedi-Betteschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK. Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for alpha3 subunit-containing GABAA receptors. Journal of Psychopharmacology, 2020; 34(3):348-357.
3. Liu C*, Meng Z#, Wiggin TD#, Yu J, Reed M, Guo F, Zhang Y, Rosbash M, Griffith LC*. A Serotonin-modulated circuit controls sleep architecture to regulate cognitive function independent of total sleep in Drosophila. Current Biology, 2019; 29: 3635-3646.
4. Duke AN#, Meng Z#, Platt DM, Atack JR, Dawson GR, Reynolds DS, Phani Babu Tiruveedhula VVN, Li GG, Stephen MR, Sieghart W, Cook JM, Rowlett JK. Evidence that sedative effects of benzodiazepines involve unexpected GABAA receptor subtypes: quantitative observation studies in Rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics, 2018; 366:145-157.
5. Meng Z, Rowlett JK. Self-administration of progesterone and synthetic neuroactive steroids by male rhesus monkeys. Drug and Alcohol Dependence, 2016; 165:265-9 6. Meng Z*, Liu C, Yu C, Ma Y*. Transcranial direct current stimulation of the frontal-parietal-temporal area attenuates smoking behavior. Journal of Psychiatric Research, 2014; 54:19-25.
